CLOSTRIDIOIDES DIFFICILE TOXIN B SUBVERTS GERMINAL CENTER AND ANTIBODY RECALL RESPONSES BY STIMULATING A DRUG-TREATABLE CXCR4-DEPENDENT MECHANISM

Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism

Summary: Recurrent Clostridioides difficile infection (CDI) results in significant morbidity and mortality.We previously established that CDI in mice does not protect against reinfection and is associated with poor pathogen-specific B cell memory (Bmem), recapitulating our observations with human Bmem.Here, we demonstrate that the secreted toxin Tc

read more

Conceptual Bases and Implementation of the EU Youth Policy

Europe is making significant efforts to create a common space where not only common political institutions and values, but also common future is to be shaped.And it is young people who is selected to be the main policy object for building common European identity.To this end in recent years, the European Union has worked out the institutional mecha

read more

Serum neopterin concentrations and tryptophan degradation pattern in patients with late stage larynx carcinoma

As the disease-free 5-year-survival of late stage laryngeal carcinoma patients is extremely low, indoleamine-2,3-dioxygenase-1 (IDO)-induced tryptophan degradation may represent an immune escape mechanism which plays an important role in cancer spreading in advanced stage laryngeal cancers.We examined whether Blade Guards the late stage laryngeal c

read more

Design of intrinsically safe field source signal transmission device for electrical method monitoring system with adaptive grounding resistance

Electrical monitoring technology is widely applied in mines with high risk of water inrush because of its high sensitivity to the change of coal resistivity.However, due to the complex working environment of the two lanes of the underground working face, the ground conditions between the different field source emission monitoring electrodes are qui

read more

Towards Understanding the Key Signature Pathways Associated from Differentially Expressed Gene Analysis in an Indian Prostate Cancer Cohort

Prostate cancer (PCa) is one of the most prevalent cancers among men in India.Although studies on PCa have dealt with genetics, genomics, and the environmental influence in the causality of PCa, not many studies employing the Next Generation Sequencing (NGS) approaches of PCa have been carried out.In our previous study, we identified some causal ge

read more